MINISTRY OF EDUCATION AND TRAINING HANOI NATIONAL UNIVERSITY OF EDUCATION NGUYEN VAN TINH LINK PREDICTION IN HETEROGENEOUS INFORMATION NETWORKS AND ITS APPLICATIONS IN PREDICTING ASSOCIATIONS BETWEEN NON-CODING RNAS AND DISEASES DOCTORAL DISSERTATION IN COMPUTER SCIENCE HANOI-2023 MINISTRY OF EDUCATION AND TRAINING HANOI NATIONAL UNIVERSITY OF EDUCATION NGUYEN VAN TINH LINK PREDICTION IN HETEROGENEOUS INFORMATION NETWORKS AND ITS APPLICATIONS IN PREDICTING ASSOCIATIONS BETWEEN NON-CODING RNAS AND DISEASES Major: Computer Science Code: 9480101 DOCTORAL DISSERTATION IN COMPUTER SCIENCE SUPERVISORS 1. Assoc. Prof. Dr. TRAN DANG HUNG 2. Dr. LE THI TU KIEN Hanoi-2023 i AUTHORSHIP'S DECLARATION I, NGUYEN VAN TINH, affirm that the dissertation entitled “Link prediction in heterogeneous information networks and its applications in predicting associations between non-coding RNAs and diseases” has been completed by myself under the supervision of Assoc.Prof.Dr. Tran Dang Hung and Dr. Le Thi Tu Kien. I assure some points as follows: - This dissertation was done in the Ph.D. research time at Hanoi National University of Education. - This work has not been submitted for any other degrees or qualifications at Hanoi National University of Education or any other institutions. - Appropriate acknowledgment has been given in the thesis where references have been made to the other published works. - The submitted thesis is my own, except the work in the collaboration has been included. The collaborative contributions have been indicated. Hanoi, 2023 Ph.D. Student SUPERVISORS: 1. Assoc. Prof. Dr. TRAN DANG HUNG 2. Dr. LE THI TU KIEN